Apertura 2022 Primera Division
| Fecha #1 | 15-05-2022 08:00 | Cerveceros FC | 5 : 2 | Hayden F. C. | |
| 15-05-2022 08:00 | Deportivo Libertadores | 1 : 3 | Resto Del Mundo | ||
| 15-05-2022 09:40 | Irapuatense | 3 : 0 | Latinos | ||
| 15-05-2022 09:40 | Paris FC | 2 : 3 | Real Villa | ||
| 15-05-2022 11:20 | Atlas | 0 : 5 | Deportivo River | ||
| 15-05-2022 11:20 | Cruz Azul | 0 : 1 | Deportivo Niupi | ||
| Fecha #2 | 22-05-2022 08:00 | Hayden F. C. | 2 : 0 | Paris FC | |
| 22-05-2022 08:00 | Real Villa | 2 : 2 | Resto Del Mundo | ||
| 22-05-2022 08:00 | Cerveceros FC | 2 : 0 | Deportivo Libertadores | ||
| 22-05-2022 09:40 | Deportivo River | 2 : 3 | Potros FC | ||
| 22-05-2022 09:40 | Atlas | 0 : 4 | Latinos | ||
| 22-05-2022 09:40 | Deportivo Niupi | 1 : 0 | Irapuatense | ||
| 22-05-2022 11:20 | Cruz Azul | 7 : 2 | Real Madrid | ||
| Fecha #3 | 29-05-2022 08:00 | Atlas | 5 : 2 | Real Madrid | |
| 29-05-2022 09:40 | Latinos | 1 : 2 | Potros FC | ||
| 29-05-2022 09:40 | Deportivo Niupi | 2 : 1 | Real Jalisco | ||
| 29-05-2022 11:20 | Cruz Azul | 3 : 1 | Deportivo River | ||
| Fecha #4 | 05-06-2022 08:00 | Paris FC | 0 : 1 | Resto Del Mundo | |
| 05-06-2022 08:00 | Deportivo Libertadores | 4 : 5 | Real Madrid | ||
| 05-06-2022 08:00 | Cerveceros FC | 2 : 1 | Real Villa | ||
| 05-06-2022 09:40 | Latinos | 0 : 1 | Real Jalisco | ||
| 05-06-2022 09:40 | Cruz Azul | 0 : 4 | Irapuatense | ||
| 05-06-2022 09:40 | Atlas | 0 : 6 | Potros FC | ||
| 05-06-2022 11:20 | Deportivo River | 2 : 2 | Morelos FC | ||
| 05-06-2022 11:20 | Deportivo Niupi | 0 : 0 | Hayden F. C. | ||
| Fecha #5 | 12-06-2022 08:00 | Hayden F. C. | 1 : 0 | Real Villa | |
| 12-06-2022 08:00 | Deportivo Durango | 1 : 3 | Resto Del Mundo | ||
| 12-06-2022 08:00 | Paris FC | 2 : 2 | Potros FC | ||
| 12-06-2022 09:40 | Morelos FC | 1 : 4 | Real Jalisco | ||
| 12-06-2022 09:40 | Deportivo Libertadores | 3 : 2 | Irapuatense | ||
| 12-06-2022 09:40 | Cerveceros FC | 0 : 3 | Latinos | ||
| 12-06-2022 11:20 | Deportivo River | 4 : 2 | Real Madrid | ||
| 12-06-2022 11:20 | Atlas | 3 : 1 | Cruz Azul | ||
| Fecha #6 | 19-06-2022 08:00 | Deportivo Libertadores | 0 : 3 | Hayden F. C. | |
| 19-06-2022 08:00 | Deportivo Durango | 1 : 4 | Paris FC | ||
| 19-06-2022 08:00 | Atlas | 1 : 0 | Real Villa | ||
| 19-06-2022 09:40 | Potros FC | 1 : 1 | Resto Del Mundo | ||
| 19-06-2022 09:40 | Deportivo Honduras | 3 : 2 | Irapuatense | ||
| 19-06-2022 09:40 | Deportivo Niupi | 0 : 3 | Latinos | ||
| 19-06-2022 11:20 | Deportivo River | 0 : 4 | Real Jalisco | ||
| 19-06-2022 11:20 | Cerveceros FC | 4 : 1 | Cruz Azul | ||
| 19-06-2022 11:20 | Morelos FC | 4 : 0 | Real Madrid | ||
| Fecha #7 | 26-06-2022 08:00 | Bahia | 1 : 0 | Deportivo Durango | |
| 26-06-2022 08:00 | Irapuatense | 2 : 3 | Real Villa | ||
| 26-06-2022 08:00 | Deportivo Libertadores | 3 : 0 | Paris FC | ||
| 26-06-2022 09:40 | Cruz Azul | 0 : 4 | Real Jalisco | ||
| 26-06-2022 09:40 | Atlas | 0 : 1 | Deportivo Niupi | ||
| 26-06-2022 09:40 | Deportivo River | 1 : 4 | Latinos | ||
| 26-06-2022 11:20 | Morelos FC | 2 : 5 | Potros FC | ||
| 26-06-2022 11:20 | Hayden F. C. | 1 : 2 | Deportivo Honduras | ||
| 26-06-2022 11:20 | Real Madrid | 0 : 3 | Resto Del Mundo | ||
| Fecha #8 | 03-07-2022 08:00 | Deportivo Durango | 0 : 5 | Deportivo Libertadores | |
| 03-07-2022 08:00 | Morelos FC | 2 : 2 | Resto Del Mundo | ||
| 03-07-2022 09:40 | Irapuatense | 3 : 3 | Real Madrid | ||
| 03-07-2022 09:40 | Deportivo Niupi | 1 : 3 | Paris FC | ||
| 03-07-2022 11:20 | Deportivo Honduras | 2 : 3 | Potros FC | ||
| 03-07-2022 11:20 | Cerveceros FC | 0 : 3 | Real Jalisco | ||
| Fecha #9 | 10-07-2022 08:00 | Latinos | 7 : 1 | Morelos FC | |
| 10-07-2022 08:00 | Deportivo Libertadores | 1 : 1 | Real Villa | ||
| 10-07-2022 08:00 | Deportivo Durango | 0 : 4 | Hayden F. C. | ||
| 10-07-2022 09:40 | Cruz Azul | 0 : 5 | Resto Del Mundo | ||
| 10-07-2022 09:40 | Deportivo Niupi | 1 : 4 | Deportivo Honduras | ||
| 10-07-2022 09:40 | Irapuatense | 2 : 3 | Potros FC | ||
| 10-07-2022 11:20 | Bahia | 3 : 0 | Deportivo River | ||
| 10-07-2022 11:20 | Atlas | 0 : 4 | Real Jalisco | ||
| 10-07-2022 11:20 | Cerveceros FC | 3 : 1 | Real Madrid | ||
| Fecha #10 | 17-07-2022 08:00 | Cerveceros FC | 4 : 1 | Irapuatense | |
| 17-07-2022 08:00 | Deportivo River | 2 : 4 | Paris FC | ||
| 17-07-2022 08:00 | Potros FC | 3 : 0 | Real Villa | ||
| 17-07-2022 09:40 | Deportivo Libertadores | 1 : 4 | Latinos | ||
| 17-07-2022 09:40 | Atlas | 3 : 3 | Paris FC | ||
| 17-07-2022 09:40 | Deportivo Durango | 2 : 3 | Deportivo Niupi | ||
| 17-07-2022 11:20 | Real Jalisco | 7 : 0 | Resto Del Mundo | ||
| 17-07-2022 11:20 | Bahia | 1 : 5 | Deportivo Honduras | ||
| 17-07-2022 11:20 | Cruz Azul | 1 : 2 | Hayden F. C. | ||
| 17-07-2022 13:00 | Morelos FC | 2 : 1 | Real Madrid | ||
| Fecha #11 | 24-07-2022 08:00 | Deportivo Libertadores | 0 : 0 | Resto Del Mundo | |
| 24-07-2022 08:00 | Bahia | 1 : 2 | Hayden F. C. | ||
| 24-07-2022 08:00 | Real Madrid | 0 : 3 | Real Villa | ||
| 24-07-2022 09:40 | Paris FC | 0 : 2 | Real Jalisco | ||
| 24-07-2022 09:40 | Deportivo Honduras | 3 : 2 | Latinos | ||
| 24-07-2022 09:40 | Deportivo River | 2 : 1 | Irapuatense | ||
| 24-07-2022 11:20 | Cruz Azul | 0 : 2 | Potros FC | ||
| 24-07-2022 11:20 | Cerveceros FC | 3 : 3 | Deportivo Niupi | ||
| Fecha #12 | 07-08-2022 08:00 | Cerveceros FC | 3 : 1 | Resto Del Mundo | |
| 07-08-2022 08:00 | Deportivo Durango | 2 : 4 | Real Madrid | ||
| 07-08-2022 08:00 | Deportivo Libertadores | 0 : 4 | Potros FC | ||
| 07-08-2022 09:40 | Deportivo Niupi | 1 : 4 | Real Villa | ||
| 07-08-2022 09:40 | Atlas | 0 : 5 | Morelos FC | ||
| 07-08-2022 09:40 | Bahia | 5 : 1 | Irapuatense | ||
| 07-08-2022 11:20 | Cruz Azul | 1 : 3 | Latinos | ||
| 07-08-2022 11:20 | Morelos FC | 3 : 1 | Paris FC | ||
| 07-08-2022 11:20 | Deportivo Honduras | 0 : 2 | Real Jalisco | ||
| 07-08-2022 13:00 | Deportivo River | 1 : 2 | Hayden F. C. | ||
| Fecha #13 | 14-08-2022 08:00 | Atlas | 1 : 5 | Cerveceros FC | |
| 14-08-2022 08:00 | Bahia | 4 : 2 | Resto Del Mundo | ||
| 14-08-2022 08:00 | Latinos | 0 : 3 | Paris FC | ||
| 14-08-2022 09:40 | Deportivo Niupi | 0 : 6 | Potros FC | ||
| 14-08-2022 09:40 | Hayden F. C. | 1 : 1 | Irapuatense | ||
| 14-08-2022 09:40 | Deportivo Honduras | 2 : 0 | Morelos FC | ||
| 14-08-2022 11:20 | Deportivo Libertadores | 1 : 1 | Real Jalisco | ||
| 14-08-2022 11:20 | Cruz Azul | 1 : 0 | Deportivo Durango | ||
| 14-08-2022 11:20 | Deportivo River | 8 : 2 | Real Villa | ||
| Fecha #14 | 28-08-2022 08:00 | Morelos FC | 0 : 0 | Real Villa | |
| 28-08-2022 08:00 | Deportivo Libertadores | 5 : 0 | Deportivo Niupi | ||
| 28-08-2022 08:00 | Deportivo Durango | 0 : 3 | Irapuatense | ||
| 28-08-2022 09:40 | Hayden F. C. | 0 : 4 | Real Jalisco | ||
| 28-08-2022 09:40 | Atlas | 1 : 6 | Deportivo Honduras | ||
| 28-08-2022 09:40 | Latinos | 4 : 2 | Real Madrid | ||
| 28-08-2022 11:20 | Bahia | 1 : 0 | Paris FC | ||
| 28-08-2022 11:20 | Cruz Azul | 0 : 2 | Deportivo Honduras | ||
| 28-08-2022 11:20 | Deportivo River | 4 : 3 | Resto Del Mundo | ||
| 28-08-2022 13:00 | Cerveceros FC | 1 : 1 | Potros FC | ||
| Fecha #15 | 04-09-2022 08:00 | Deportivo Honduras | 3 : 2 | Resto Del Mundo | |
| 04-09-2022 08:00 | Deportivo Libertadores | 0 : 2 | Morelos FC | ||
| 04-09-2022 09:40 | Latinos | 7 : 1 | Real Villa | ||
| 04-09-2022 09:40 | Cerveceros FC | 4 : 2 | Deportivo River | ||
| 04-09-2022 09:40 | Cruz Azul | 0 : 2 | Deportivo Niupi | ||
| 04-09-2022 11:20 | Atlas | 0 : 3 | Hayden F. C. | ||
| 04-09-2022 11:20 | Irapuatense | 3 : 0 | Paris FC | ||
| 04-09-2022 11:20 | Potros FC | 11 : 2 | Real Madrid | ||
| Fecha #16 | 11-09-2022 08:00 | Bahia | 5 : 1 | Real Villa | |
| 11-09-2022 08:00 | Cruz Azul | 0 : 5 | Deportivo Libertadores | ||
| 11-09-2022 09:40 | Atlas | 2 : 1 | Resto Del Mundo | ||
| 11-09-2022 09:40 | Deportivo Honduras | 5 : 1 | Deportivo River | ||
| 11-09-2022 09:40 | Irapuatense | 2 : 2 | Morelos FC | ||
| 11-09-2022 11:20 | Bahia | 6 : 2 | Morelos FC | ||
| 11-09-2022 11:20 | Hayden F. C. | 1 : 5 | Latinos | ||
| 11-09-2022 11:20 | Deportivo Niupi | 3 : 3 | Real Madrid | ||
| 11-09-2022 13:00 | Potros FC | 2 : 3 | Real Jalisco | ||
| Fecha #17 | 20-09-2022 08:00 | Cerveceros FC | 6 : 1 | Paris FC | |
| 20-09-2022 08:00 | Atlas | 0 : 5 | Irapuatense | ||
| 20-09-2022 08:00 | Real Jalisco | 6 : 1 | Real Villa | ||
| 20-09-2022 09:40 | Deportivo Honduras | 1 : 0 | Deportivo Libertadores | ||
| 20-09-2022 09:40 | Bahia | 3 : 6 | Cerveceros FC | ||
| 20-09-2022 09:40 | Latinos | 14 : 1 | Resto Del Mundo | ||
| 20-09-2022 11:20 | Hayden F. C. | 0 : 3 | Potros FC | ||
| 20-09-2022 11:20 | Paris FC | 1 : 0 | Real Madrid | ||
| 20-09-2022 11:20 | Deportivo Niupi | 1 : 4 | Deportivo River | ||
| 20-09-2022 13:00 | Cruz Azul | 1 : 4 | Morelos FC | ||
| Fecha #18 | 25-09-2022 08:00 | Deportivo Niupi | 8 : 0 | Resto Del Mundo | |
| 25-09-2022 08:00 | Bahia | 0 : 7 | Latinos | ||
| 25-09-2022 08:00 | Atlas | 2 : 3 | Deportivo Libertadores | ||
| 25-09-2022 09:40 | Cerveceros FC | 3 : 0 | Morelos FC | ||
| 25-09-2022 09:40 | Deportivo River | 0 : 5 | Potros FC | ||
| 25-09-2022 09:40 | Cruz Azul | 2 : 1 | Real Villa | ||
| 25-09-2022 11:20 | Hayden F. C. | 9 : 1 | Real Madrid | ||
| 25-09-2022 11:20 | Deportivo Honduras | 2 : 1 | Paris FC | ||
| 25-09-2022 11:20 | Irapuatense | 0 : 3 | Real Jalisco | ||
| Fecha #19 | 02-10-2022 00:00 | Bahia | 0 : 1 | Potros FC | |
| 02-10-2022 08:00 | Cerveceros FC | 3 : 0 | Hayden F. C. | ||
| 02-10-2022 08:00 | Cruz Azul | 2 : 5 | Paris FC | ||
| 02-10-2022 08:00 | Deportivo Libertadores | 3 : 0 | Deportivo River | ||
| 02-10-2022 09:40 | Deportivo Honduras | 3 : 0 | Real Villa | ||
| 02-10-2022 09:40 | Irapuatense | 2 : 3 | Resto Del Mundo | ||
| 02-10-2022 09:40 | Atlas | 0 : 6 | Latinos | ||
| 02-10-2022 11:20 | Deportivo Niupi | 1 : 1 | Morelos FC | ||
| 02-10-2022 11:20 | Real Jalisco | 4 : 2 | Real Madrid | ||